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KMID : 0861020000150010083
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Korea Journal of Herbology
2000 Volume.15 No. 1 p.83 ~ p.100
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Study on Antitumor Activity and Immunomodulatory Effect of Bujungikgibang
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具滋權/Gu, Ja-Kwan
宋昊哲/金東熙/徐榮培/朴陽春/金聖勳/Song, Ho-Chul/Kim, Dong-Hee/Seo, Young-Bae/Park, Yang-Chun/Kim, Sung-Hoon
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Abstract
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To evaluate the antitum or activity and immune response Bujungikgibang(BJ1GB) studies were done experimentally. The results were obtained as follows:
1. BJIGB extracts exhibited a weak cytotoxicity against SK-OV-3, and SK-MEL-2 cell lines. While it showed cytotoxicity against B16-Fl0 cell line up to 30% of control at concentration of 0.5 mg/ml.
2. BJIGB extracts significantly showed inhibitoty effect on DNA topoisomerase 1 from calf thymus in a dose-dependant manner.
3. BJIGB extracts showed antiadhesive rates against A549, at 30% at 0.5 mg/ml, 60% at 1 mg/ml
4. BJIGB extracts inhibited CAM angiogenesis up to 60%.
5. BJIGB extracts prolonged life span of ICR mice bearing S-180 sarcoma cells up to 130.5%.
6. In FACS analysis, the population of helper T cell was increased weakly, while cytotoxity T cell was decreased insignificantly.
7. The production of nitric oxide in RAW cell stimulated by LPS was incresed at 0.5mg/ml or more in dose dependant fashion as compared with control.
8. Proliferation rate of splenocyte was increased at 0.5mg/ml or more a dose dependant fashion as compared with control.
These results suggested that BJIGB extracts might be usefully applied for treatement of cancer and also it was nesessary to do more studies about its mechnisms.
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